Vasculitis

Vasculitis: An Overview

Vasculitis refers to a group of disorders characterized by inflammation of blood vessels, which can affect arteries, veins, or capillaries. This inflammation can lead to vessel narrowing, weakening, or even rupture, resulting in impaired blood flow and damage to affected tissues and organs. The condition may be localized to specific organs or systemic, involving multiple organ systems.

Vasculitis is classified based on the size of the blood vessels affected—large, medium, or small vessels—and can be primary (idiopathic) or secondary to infections, autoimmune disorders, medications, or malignancies. Common types include giant cell arteritis, Takayasu arteritis, polyarteritis nodosa, and granulomatosis with polyangiitis.

Symptoms vary widely depending on the type and organs involved, but common signs include fever, fatigue, weight loss, joint pain, skin rashes, and specific organ dysfunction. Diagnosis involves clinical evaluation, blood tests (e.g., inflammatory markers), imaging studies, and sometimes biopsy of affected tissues.

Treatment depends on the severity and underlying cause, often involving corticosteroids, immunosuppressants, or biologic agents. Prompt diagnosis and tailored therapy are crucial to prevent long-term complications, including organ damage. Regular follow-ups ensure disease control and early detection of relapses.